Article

The Impact of Gag Non-Cleavage Site Mutations on HIV-1 Viral Fitness from Integrative Modelling and Simulations

2020-07-05

Abstract excerpt

<h4>Summary</h4> The high mutation rate in retroviruses is one of the leading causes of drug resistance. In human immunodeficiency virus type-1 (HIV-1), synergistic mutations in its protease and the protease substrate – the Group-specific antigen (Gag) polyprotein – work together to confer drug resistance against protease inhibitors and compensate the mutations affecting viral fitness. Some Gag mutations can rest...

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Literature Corpus work: 586caa14-1725-5f63-8f93-019cb53572ff
DOI: 10.1101/2020.07.05.188326

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