Article
The immunogenicity of VP7, a rotavirus antigen resident in the endoplasmic reticulum, is enhanced by cell surface expression.
Journal of virology - 1 Oct 1990
Andrew M E, Boyle D B, Whitfeld P L, Lockett L J, Anthony I D, Bellamy A R, Both G W
Abstract excerpt
The glycoprotein VP7, the major serotype antigen of rotaviruses, is localized to the endoplasmic reticulum (ER) of the cell, where it is retained as a membrane-associated protein before assembly into mature virus particles. Wild-type VP7 expressed by a recombinant vaccinia virus was also located...
Topics
- Amino Acid Sequence
- Animals
- Antibody Formation
- Antigens, Viral
- Capsid
- Capsid Proteins
- Cell Line
- Cell Membrane
- Endoplasmic Reticulum
- Enzyme-Linked Immunosorbent Assay
- Genes, Viral
- Humans
- Influenza A virus
- Mice
- Mice, Inbred CBA