Rotavirus antigenicity is affected by the genetic context and glycosylation of VP7.

doi:10.1006/viro.1995.1232

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Article

Rotavirus antigenicity is affected by the genetic context and glycosylation of VP7.

Virology - 10 May 1995

Lazdins I, Coulson B S, Kirkwood C, Dyall-Smith M, Masendycz P J, Sonza S, Holmes I H

Abstract excerpt

Rotavirus variants resistant to neutralization were selected using monoclonal antibodies (N-MAbs) raised to VP7 of rotavirus G types 2, 3, and 6. Their neutralization resistance patterns and deduced VP7 amino acid sequences were obtained. Variants selected by two G2-specific N-MAbs from the homologous parent virus RV-5 showed single amino acid (aa) mutations in the antigenic A region. However, variants selected...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antigenic Variation
Antigens, Viral
Base Sequence
Capsid
Capsid Proteins
Cattle
DNA Primers
DNA, Viral
Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycosylation

Humans

Molecular Sequence Data

Mutation

Neutralization Tests

Rotavirus

Source

Open in PubMed

Identifiers

PMID: 7747487
DOI: 10.1006/viro.1995.1232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7747487-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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