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Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments

8 Aug 2022

Abstract excerpt

The spike protein VP4 participates in diverse steps of the rotavirus (RV) life cycle, including virus-cell attachment, internalization, modulation of endocytosis, virion morphogenesis, and virus egress. Using reverse genetics, we constructed for the first time a recombinant RV, rRV/VP4-BAP, harboring a heterologous peptide in the lectin domain (loop K145-G150) of VP4. The rRV/VP4-BAP was replication competent but...

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PMID: 35938869
DOI: 10.1128/jvi.01074-22

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