Article
Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) - 1 Oct 2011
Jia Deshui, Wei Lin, Guo Weijie, Zha Ruopeng, Bao Meiyan, Chen Zhiao, Zhao Yingjun, Ge Chao, Zhao Fangyu, Chen Taoyang, Yao Ming, Li Jinjun, Wang Hongyang, Gu Jianren, He Xianghuo
Abstract excerpt
UNLABELLED: A powerful way to identify driver genes with causal roles in carcinogenesis is to detect genomic regions that undergo frequent alterations in cancers. Here we identified 1,241 regions of somatic copy number alterations in 58 paired hepatocellular carcinoma (HCC) tumors and adjacent nontumor tissues using genome-wide single nucleotide polymorphism (SNP) 6.0 arrays. Subsequently, by integrating copy...
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