Article
Genome-wide screening of copy number alterations and LOH events in renal cell carcinomas and integration with gene expression profile.
Molecular cancer - 14 Jan 2008
Cifola Ingrid, Spinelli Roberta, Beltrame Luca, Peano Clelia, Fasoli Ester, Ferrero Stefano, Bosari Silvano, Signorini Stefano, Rocco Francesco, Perego Roberto, Proserpio Vanessa, Raimondo Francesca, Mocarelli Paolo, Battaglia Cristina
Abstract excerpt
BACKGROUND: Clear cell renal carcinoma (RCC) is the most common and invasive adult renal cancer. For the purpose of identifying RCC biomarkers, we investigated chromosomal regions and individual genes modulated in RCC pathology. We applied the dual strategy of assessing and integrating genomic and transcriptomic data, today considered the most effective approach for understanding genetic mechanisms of cancer and...
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