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Article

Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders.

PloS one - 1 Jan 2011

Voineskos Aristotle N, Lett Tristram A P, Lerch Jason P, Tiwari Arun K, Ameis Stephanie H, Rajji Tarek K, Müller Daniel J, Mulsant Benoit H, Kennedy James L

Abstract excerpt

BACKGROUND: Structural variation in the neurexin-1 (NRXN1) gene increases risk for both autism spectrum disorders (ASD) and schizophrenia. However, the manner in which NRXN1 gene variation may be related to brain morphology to confer risk for ASD or schizophrenia is unknown. METHOD/PRINCIPAL FINDINGS: 53 healthy individuals between 18-59 years of age were genotyped at 11 single nucleotide polymorphisms of the...

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Source

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Identifiers

PMID: 21687627
DOI: 10.1371/journal.pone.0020982
PMCID: PMC3110800

Genes

NRXN1

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