CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.

doi:10.3324/haematol.2011.042572

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Article

CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.

Haematologica - 1 Oct 2011

Such Esperanza, Cervera José, Terpos Evangelos, Bagán José V, Avaria Amparo, Gómez Inés, Margaix María, Ibañez Mariam, Luna Irene, Cordón Lourdes, Roig Mónica, Sanz Miguel A, Dimopoulos Meletios A, de la Rubia Javier

Abstract excerpt

Osteonecrosis of the jaw is an uncommon but potentially serious complication of bisphosphonate therapy in multiple myeloma. Previous studies showed that the presence of one or two minor alleles of the cytochrome P450, subfamily 2C polypeptide 8 gene (CYP2C8) polymorphism rs1934951 was an independent prognostic marker associated with development of osteonecrosis of the jaw in multiple myeloma patients treated with...

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PMID: 21685474
DOI: 10.3324/haematol.2011.042572
PMCID: PMC3186320

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