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Genetic factors related with early onset of osteonecrosis of the jaw in patients with multiple myeloma under zoledronic acid therapy.

Leukemia & lymphoma - 1 Oct 2017

Kastritis Efstathios, Melea Pelagia, Bagratuni Tina, Melakopoulos Ioannis, Gavriatopoulou Maria, Roussou Maria, Migkou Magdalini, Eleutherakis-Papaiakovou Evangelos, Terpos Evangelos, Dimopoulos Meletios A

Abstract excerpt

Specific genetic polymorphisms (SNPs) have been correlated with the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in small series. We screened 140 myeloma patients (36 patients with and 104 without BRONJ) for the presence of previously identified SNPs in PPARG and CYP2C8 genes. All the patients received exclusively zolendronic acid (ZA) therapy and were followed prospectively for BRONJ....

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PMID: 28604257
DOI: 10.1080/10428194.2017.1300889

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PPARG

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