Microarray assessment of methylation in individual mouse blastocyst stage embryos shows that in vitro culture may have widespread genomic effects

Abstract excerpt

BACKGROUND: Although assisted reproductive technology (ART) is reported to result in abnormal genomic imprinting and/or altered genomic methylation, few if any studies have used high-throughput methods to analyze genomic methylation in ART embryos. We hypothesized that a microarray-based assessment of genomic methylation could be used to reveal differences between ART and normal preimplantation embryos. METHODS:...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Assisted Reproductive Technology and Twin Pregnancy
• Share to Genetic Syndromes and Imprinting
• Share to Reproductive Biology and Fertility