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Article

Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles.

Genome research - 1 Sept 2011

Wang Jianbin, Czech Benjamin, Crunk Amanda, Wallace Adam, Mitreva Makedonka, Hannon Gregory J, Davis Richard E

Abstract excerpt

Eukaryotic cells express several classes of small RNAs that regulate gene expression and ensure genome maintenance. Endogenous siRNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs) mainly control gene and transposon expression in the germline, while microRNAs (miRNAs) generally function in post-transcriptional gene silencing in both somatic and germline cells. To provide an evolutionary and developmental...

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Identifiers

PMID: 21685128
DOI: 10.1101/gr.121426.111
PMCID: PMC3166831

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