Article
Pathogenicity of a human thyroglobulin peptide (2340-2359) in mice with high or low genetic susceptibility to thyroiditis.
Immunology - 1 Nov 2007
Hatzioannou Aikaterini, Liakata Elisavet, Karras Evangelos, Thrasyvoulides Apollon, Alevizaki Maria, Lymberi Peggy
Abstract excerpt
We have previously identified a 20-mer peptide of human thyroglobulin (hTg), p2340 (aa2340-2359), which induced experimental autoimmune thyroiditis (EAT) in AKR/J (H-2(k)) and HLA-DR3 transgenic mice. In this study, we investigated the thyroiditogenic potential of p2340 in 'high responder' CBA/J...
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