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Article

Characterization of cells cultured from human giant-cell tumors of bone. Phenotypic relationship to the monocyte-macrophage and osteoclast.

Clinical orthopaedics and related research - 1 Sept 1990

Komiya S, Sasaguri Y, Inoue A, Nakashima M, Yamamoto S, Yanagida I, Morimatsu M

Abstract excerpt

Cell culture techniques were used to clarify the histogenesis of giant-cell tumor of bone. Even after passage, nearly all of the mononuclear cells possessed tartrate-resistant acid phosphatase and receptors for eel calcitonin, which are both phenotypic markers for osteoclasts. Eel calcitonin prod...

Topics

Biomarkers
Bone Neoplasms
Bone Resorption
Cyclic AMP
Giant Cell Tumors
Histocytochemistry
Humans
In Vitro Techniques
Leukocytes, Mononuclear
Osteoclasts
Phenotype
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2168302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2168302-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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