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Article

Factor VIII haplotypes frequencies in Tunisian hemophiliacs A.

Diagnostic pathology - 17 Jun 2011

Elmahmoudi Hejer, Belhedi Nejla, Jlizi Asma, Zahra Kaouther, Meddeb Balkis, Ben Ammar Elgaaied Amel, Gouider Emna

Abstract excerpt

BACKGROUND: The development of inhibitors against factor 8 (F8) is the most serious complication of replacement therapy with F8 in children with severe hemophilia. It was suggested that mismatched F8 replacement therapy may be a risk factor for the development of anti-factor F8 alloantibodies. Recently four single nucleotide polymorphisms (SNPs) encoding six distinct haplotypes, designated H1 through H6, were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21682900
DOI: 10.1186/1746-1596-6-54
PMCID: PMC3148954

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