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Article

Investigating the influence of LCT rs3754689 polymorphism on inhibitor development in Iranian and Afghan patients with severe hemophilia A.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jan 2020

Bahrami Zadegan Sobhan, Mousavi Sayed H, Damavandi Narges, Samiee Aref Mohammad H, Zeinali Sirous

Abstract excerpt

: Development of alloantibodies against factor VIII (FVIII) in patients with severe hemophilia A is the main complication of FVIII replacement therapy. There are many studies indicating several genetic factors associated with inhibitor development. A recent study showed that there is a correlation between the risk of inhibitor development and LCT rs3754689 polymorphism among Italian hemophilia A patients. The aim...

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PMID: 31644449
DOI: 10.1097/MBC.0000000000000860

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