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Article

Genetic Deletion of Chemokine Receptor Ccr6 Decreases Atherogenesis inApoE-Deficient Mice

17 Jun 2011

Abstract excerpt

RATIONALE: The chemokine receptor Ccr6 is a G-protein-coupled receptor expressed on various types of leukocytes identified in mouse atherosclerotic lesions. Recent evidence suggests that both CCR6 and its ligand CCL20 are also present in human atheroma; however, their functional roles in atherogenesis remain undefined. OBJECTIVE: Our objective was to delineate the role of Ccr6 in atherogenesis in the...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 21680896
DOI: 10.1161/circresaha.111.242578

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