Article
IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers.
Cytokine - 1 Apr 2010
Sasson Sarah C, Smith Sandy, Seddiki Nabila, Zaunders John J, Bryant Adam, Koelsch Kersten K, Weatherall Christopher, Munier Mee-Ling, McGinley Ciara, Yeung Julie, Mulligan Stephen P, Moore John, Cooper David A, Milliken Sam, Kelleher Anthony D
Abstract excerpt
The interleukin (IL)-7 receptor (IL-7R) is expressed on human pre-B but not mature B-cells. We hypothesised that aberrant expression of IL-7R contributes to B-cell oncogenesis. Surface expression of IL-7R components CD127 and CD132, and intracellular Ki-67 and Bcl-2 were examined by flow cytometry on peripheral blood or bone marrow mononuclear cells (PBMC; BMMC) from patients with B-cell derived neoplasms,...
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