Article
Human liver enzymes responsible for metabolic elimination of tyramine; a vasopressor agent from daily food.
Drug metabolism letters - 1 Aug 2011
Niwa Toshiro, Murayama Norie, Umeyama Hiromi, Shimizu Makiko, Yamazaki Hiroshi
Abstract excerpt
Dietary tyramine is associated with hypertensive crises because of its ability to induce the release of catecholamines. The roles of monoamine oxidase (MAO); flavin-containing monooxygenase (FMO); and cytochrome P450 2D6 (CYP2D6) were studied in terms of the enzymatic elimination of tyramine in vitro at a substrate concentration of 1.0 µM; which is relevant to in vivo serum concentrations. Tyramine elimination by...
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