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Article

No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients.

Human psychopharmacology - 1 Jan 2000

Ikenouchi-Sugita Atsuko, Yoshimura Reiji, Kishi Taro, Umene-Nakano Wakako, Hori Hikaru, Katsuki Asuka, Saito Kazuyoshi, Iwata Nakao, Tanaka Yoshiya, Nakamura Jun

Abstract excerpt

BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. Recent studies have suggested that BDNF plays a role in the pathogenesis of psychiatric symptoms in patients with systemic lupus erythematosus (SLE). OBJECTIVES: We hypothesized that the polymorphism of BDNF Val66Met is...

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Source

Identifiers

PMID: 21678493
DOI: 10.1002/hup.1203

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 11 closest

No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients.PMID 21678493Read ↗

The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus.Semantic proximity Read ↗

Are variations in whole blood BDNF level associated with the BDNF Val66Met polymorphism in patients with first episode depression?Semantic proximity Read ↗

Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression.Semantic proximity Read ↗

The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.Semantic proximity Read ↗

High blood levels of brain-derived neurotrophic factor (BDNF) mRNA in early psychosis are associated with inflammatory markers.Semantic proximity Read ↗

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in febrile seizures.Semantic proximity Read ↗

Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus.Semantic proximity Read ↗

Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism.Semantic proximity Read ↗

Predisposition to epilepsy in fragile X syndrome: does the Val66Met polymorphism in the BDNF gene play a role?Semantic proximity Read ↗

Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course.Semantic proximity Read ↗

No major clinical impact of Val66Met BDNF gene polymorphism on temporal lobe epilepsy.Semantic proximity Read ↗

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