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Article

Predisposition to epilepsy in fragile X syndrome: does the Val66Met polymorphism in the BDNF gene play a role?

Epilepsy & behavior : E&B - 1 Nov 2011

Tondo Mireia, Poo Pilar, Naudó Montserrat, Ferrando Teresa, Genovés Jordi, Molero Marta, Martorell Loreto

Abstract excerpt

Epilepsy is detected in about 23% of patients with fragile X syndrome (FXS). Absence or reduced levels of the fragile X mental retardation protein (FMRP), a global regulator of translation in neurons and an important factor in synaptic plasticity, produce the observed epileptic patterns. The brain-derived neurotrophic factor (BDNF) gene is a specific regulator of synaptic plasticity, and disturbances in its...

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Identifiers

PMID: 21890420
DOI: 10.1016/j.yebeh.2011.08.003

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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