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Article

Stochastic expression of the interferon-β gene.

PLoS biology - 1 Jan 2012

Zhao Mingwei, Zhang Jiangwen, Phatnani Hemali, Scheu Stefanie, Maniatis Tom

Abstract excerpt

Virus infection of mammalian cells induces the production of high levels of type I interferons (IFNα and β), cytokines that orchestrate antiviral innate and adaptive immunity. Previous studies have shown that only a fraction of the infected cells produce IFN. However, the mechanisms responsible for this stochastic expression are poorly understood. Here we report an in depth analysis of IFN-expressing and...

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Identifiers

PMID: 22291574
DOI: 10.1371/journal.pbio.1001249
PMCID: PMC3265471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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