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Article

Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency

20 Feb 2014

Abstract excerpt

Herpesviruses establish a lifelong latent infection posing the risk for virus reactivation and disease. In cytomegalovirus infection, expression of the major immediate early (IE) genes is a critical checkpoint, driving the lytic replication cycle upon primary infection or reactivation from latency. While it is known that type I interferon (IFN) limits lytic CMV replication, its role in latency and reactivation...

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PMID: 24586165
DOI: 10.1371/journal.ppat.1003962

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