Article
Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice.
Virology - 1 Mar 2007
Kiyotani Katsuhiro, Sakaguchi Takemasa, Kato Atsushi, Nagai Yoshiyuki, Yoshida Tetsuya
Abstract excerpt
The present study was undertaken to clarify the role of Sendai virus (SeV) V protein, which has been shown to downregulate IFN-beta induction through inhibition of IRF-3 activation, in viral pathogenesis. Mice infected with rSeV mutants, deficient in V expression or expressing V lacking the C-ter...
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