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Article

A leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy.

Scientific reports - 14 Sept 2018

Moreau Adrien, Gosselin-Badaroudine Pascal, Mercier Aurélie, Burger Bettina, Keller Dagmar I, Chahine Mohamed

Abstract excerpt

Dilated cardiomyopathy (DCM) is a structural heart disease that causes dilatation of cardiac chambers and impairs cardiac contractility. The SCN5A gene encodes Nav1.5, the predominant cardiac sodium channel alpha subunit. SCN5A mutations have been identified in patients with arrhythmic disorders associated with DCM. The characterization of Nav1.5 mutations located in the voltage sensor domain (VSD) and associated...

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Identifiers

PMID: 30218094
DOI: 10.1038/s41598-018-31772-0
PMCID: PMC6138662

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