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Article

Large-scale mouse knockouts and phenotypes.

Wiley interdisciplinary reviews. Systems biology and medicine - 1 Jan 2000

Ramírez-Solis Ramiro, Ryder Edward, Houghton Richard, White Jacqueline K, Bottomley Joanna

Abstract excerpt

Standardized phenotypic analysis of mutant forms of every gene in the mouse genome will provide fundamental insights into mammalian gene function and advance human and animal health. The availability of the human and mouse genome sequences, the development of embryonic stem cell mutagenesis technology, the standardization of phenotypic analysis pipelines, and the paradigm-shifting industrialization of these...

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PMID: 22899600
DOI: 10.1002/wsbm.1183

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