Article
Bioconjugation using mutant glycosyltransferases for the site-specific labeling of biomolecules with sugars carrying chemical handles.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Ramakrishnan Boopathy, Boeggeman Elizabeth, Pasek Marta, Qasba Pradman K
Abstract excerpt
This chapter presents a technique that employs mutant glycosyltransferase enzymes for the site-specific bioconjugation of biomolecules via a glycan moiety to facilitate the development of a targeted drug delivery system. The target specificity of this methodology is based on unique sugar residues that are present on glycoproteins or engineered glycopeptides. The glycosyltransferases used in this approach have...
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