Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay.

doi:10.1371/journal.pone.0020251

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Article

Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay.

PloS one - 1 Jan 2011

Campino Susana, Auburn Sarah, Kivinen Katja, Zongo Issaka, Ouedraogo Jean-Bosco, Mangano Valentina, Djimde Abdoulaye, Doumbo Ogobara K, Kiara Steven M, Nzila Alexis, Borrmann Steffen, Marsh Kevin, Michon Pascal, Mueller Ivo, Siba Peter, Jiang Hongying, Su Xin-Zhuan, Amaratunga Chanaki, Socheat Duong, Fairhurst Rick M, Imwong Mallika, Anderson Timothy, Nosten François, White Nicholas J, Gwilliam Rhian, Deloukas Panos, MacInnis Bronwyn, Newbold Christopher I, Rockett Kirk, Clark Taane G, Kwiatkowski Dominic P

Abstract excerpt

The diversity in the Plasmodium falciparum genome can be used to explore parasite population dynamics, with practical applications to malaria control. The ability to identify the geographic origin and trace the migratory patterns of parasites with clinically important phenotypes such as drug resistance is particularly relevant. With increasing single-nucleotide polymorphism (SNP) discovery from ongoing Plasmodium...

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PMID: 21673999
DOI: 10.1371/journal.pone.0020251
PMCID: PMC3108946

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