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Article

Spermatogonial fate in mice with increased activin A bioactivity and testicular somatic cell tumours

26 Jul 2023

Abstract excerpt

Adult male fertility depends on spermatogonial stem cells (SSCs) which undergo either self-renewal or differentiation in response to microenvironmental signals. Activin A acts on Sertoli and Leydig cells to regulate key aspects of testis development and function throughout life, including steroid production. Recognising that activin A levels are elevated in many pathophysiological conditions, this study...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 37564373
DOI: 10.3389/fcell.2023.1237273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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