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Article

Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells

5 Apr 2012

Abstract excerpt

In western countries, 60% of all malignancies diagnosed in men between 17-45 years of age are germ cell tumors (GCT). GCT arise from the common precursor lesion carcinoma in situ, which transforms within an average of 9 years into invasive Type-II GCTs. Seminomas are considered to be the default developmental pathway of carcinoma in situ cells and the seminoma-like cell line TCam-2 has been used to study seminoma...

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PMID: 22489004
DOI: 10.1002/gcc.21958

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