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Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway

15 Sept 2022

Abstract excerpt

Leydig cells in fetal testes play crucial roles in masculinizing fetuses through androgen production. Gene knockout studies have revealed that growth factors are implicated in fetal Leydig cell (FLC) differentiation, but little is known about the mechanisms regulating this process. We investigate this issue by characterizing FLC progenitor cells using single-cell RNA sequencing. The sequence datasets suggest that...

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PMID: 36109592
DOI: 10.1038/s42003-022-03941-5

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