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Updating germ cell tumour pathogenesis – the ability of seminomas for FOXA2‐driven extra‐embryonic differentiation

2 Jun 2023

Abstract excerpt

AIMS: Testicular germ cell tumours are the most common solid malignancies in young men of age 14-44 years. It is generally accepted that both seminomas and non-seminomas arise from a common precursor, the germ cell neoplasia in-situ, which itself is the result of a defective (primordial) germ cell development. The stem cell-like population of the non-seminomas, the embryonal carcinoma, is capable of the...

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PMID: 37265221
DOI: 10.1111/his.14933

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