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Article

Environmental enrichment lessens cognitive decline in APP23 mice without affecting brain sirtuin expression.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Polito Letizia, Chierchia Armando, Tunesi Marta, Bouybayoune Ihssane, Kehoe Patrick Gavin, Albani Diego, Forloni Gianluigi

Abstract excerpt

Environmental enrichment (EE) is a non-pharmacological intervention reported to counteract pathological signs in models of Alzheimer's disease (AD). We developed EE protocols in APP23 mice and evaluated how they influenced cognitive decline and brain amyloid-β (Aβ) burden. We also investigated the involvement of sirtuins (SIRTs) as a possible molecular mediator of EE, by assessing hippocampal and cortical mRNA...

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Source

Identifiers

PMID: 24961946
DOI: 10.3233/JAD-131430

Genes

SIRT1
SIRT7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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