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Article

The ubiquitin ligase Rsp5 is required for ribosome stability in Saccharomyces cerevisiae.

RNA (New York, N.Y.) - 1 Aug 2011

Shcherbik Natalia, Pestov Dimitri G

Abstract excerpt

Rsp5p is a conserved HECT-domain ubiquitin ligase with diverse roles in cellular physiology. Here we report a previously unknown role of Rsp5p in facilitating the stability of the cytoplasmic ribosome pool in budding yeast. Yeast strains carrying temperature-sensitive mutations in RSP5 showed a progressive decline in levels of 18S and 25S rRNAs and accumulation of rRNA decay fragments when cells grown in rich...

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Identifiers

PMID: 21665996
DOI: 10.1261/rna.2615311
PMCID: PMC3153967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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