Article
The effect of TP53 codon 72 and RNASEL codon 462 polymorphisms on the development of cervical cancer in Argentine women.
Cancer genetics - 1 May 2011
Barbisan Gisela, Contreras Anahí, Pérez Luis Orlando, Difranza Leonardo, Golijow Carlos Daniel
Abstract excerpt
Epidemiological evidence suggests that genetic factors, such as variants in cancer suppressor genes, may play an important role in the etiology of cervical carcinoma. TP53 is an outstanding cell cycle regulator, mutated in most human cancers, and RNASEL is thought to be involved in antiviral and apoptotic responses. To determine whether TP53 Arg72Pro and RNASEL Arg462Gln polymorphisms are associated with...
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