Article
Effects of mitochondrial mutations on hearing and cochlear pathology with age.
Hearing research - 1 Oct 2011
Crawley Brianna K, Keithley Elizabeth M
Abstract excerpt
Age-related hearing loss is a multi-factorial process involving genetic and environmental factors, including exposure to noise and ototoxic agents, as well as pathological processes. Among these is the accumulation of mitochondrial DNA mutations and deletions. The creation of a transgenic mouse with a loss-of-function deletion of the nuclear gene that encodes the polymerase required to repair damaged...
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