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Article

Age-related hearing loss involves mitochondrial DNA instability and copy number depletion in the cochlea: Insights from in vivo and in vitro models.

Hearing research - 1 Jan 2026

Turner Akil, Ding Bo, Zhu Xiaoxia, Nguyen Tam, Bazard Parveen, Frisina Robert D

Abstract excerpt

Age-related hearing loss (ARHL) is a highly prevalent sensory neurodegenerative disorder that involves various molecular mechanisms. The present study investigated if age-related oxidative stress (OS) induces alterations in mitochondrial DNA (mtDNA) copy number and heteroplasmy, using complementary in vivo and in vitro models. Aged (30-month) CBA/CaJ mice have elevated auditory brainstem response (ABR) thresholds...

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Identifiers

PMID: 41308562
DOI: 10.1016/j.heares.2025.109471

Genes

ABR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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