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Article

Somatic mtDNA mutations cause progressive hearing loss in the mouse.

Experimental cell research - 1 Nov 2007

Niu Xianzhi, Trifunovic Aleksandra, Larsson Nils-Göran, Canlon Barbara

Abstract excerpt

Mitochondrial dysfunction has been implicated in the commonly occurring age-associated hearing loss (presbyacusis). We have previously generated mtDNA mutator mice with increased levels of somatic mtDNA point mutations causing phenotypes consistent with premature ageing. We have now utilized these mice to investigate whether elevated levels of somatic mtDNA mutations affect the auditory system. The mtDNA mutator...

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PMID: 17662273
DOI: 10.1016/j.yexcr.2007.05.029

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ABR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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