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Article

Buffy coat specimens remain viable as a DNA source for highly multiplexed genome-wide genetic tests after long term storage.

Journal of translational medicine - 10 Jun 2011

Mychaleckyj Josyf C, Farber Emily A, Chmielewski Jessica, Artale Jamie, Light Laney S, Bowden Donald W, Hou Xuanlin, Marcovina Santica M

Abstract excerpt

BACKGROUND: Blood specimen collection at an early study visit is often included in observational studies or clinical trials for analysis of secondary outcome biomarkers. A common protocol is to store buffy coat specimens for future DNA isolation and these may remain in frozen storage for many years. It is uncertain if the DNA remains suitable for modern genome wide association (GWA) genotyping. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21663644
DOI: 10.1186/1479-5876-9-91
PMCID: PMC3128059

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