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The Effect of Preanalytical and Physiological Variables on Cell-Free DNA Fragmentation

9 Feb 2022

Abstract excerpt

BACKGROUND: Assays that account for the biological properties and fragmentation of cell-free DNA (cfDNA) can improve the performance of liquid biopsy. However, preanalytic and physiological differences between individuals on fragmentomic analysis are poorly defined. METHODS: We analyzed the impact of collection tube, plasma processing time, and physiology on the size distribution of cfDNA, their genome-wide...

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PMID: 35292813
DOI: 10.1093/clinchem/hvac029

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