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Article

p53 Binds to estrogen receptor 1 promoter in human breast cancer cells.

Pathology oncology research : POR - 1 Apr 2012

Rasti Mozhgan, Arabsolghar Rita, Khatooni Zahed, Mostafavi-Pour Zoherh

Abstract excerpt

p53 is a tumor suppressor protein that regulates estrogen receptor 1 (ESR1) expression. To investigate the mechanism of ESR1 gene regulation by p53, chromatin immunoprecipitation was applied to assess the binding of p53, DNMT1, HDAC1 and MeCP2 to both silenced ESR1 promoter in MDA-MB-468 cells and active ESR1 promoter in MCF-7 breast cancer cells. The results of chromatin immunoprecipitation experiments showed...

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Topics

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Share to Chromatin Immunoprecipitation
Share to CpG Islands
Share to DNA (Cytosine-5-)-Methyltransferase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to Estrogen Receptor alpha

Share to Histone Deacetylase 1

Share to Methyl-CpG-Binding Protein 2

Share to Regulatory Sequences, Nucleic Acid

Source

Identifiers

PMID: 21655924
DOI: 10.1007/s12253-011-9423-6

Genes

ESR1
DNMT1
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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