Article
Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum.
Journal of virology - 1 Aug 2011
van Gils Marit J, Edo-Matas Diana, Bowles Emma J, Burger Judith A, Stewart-Jones Guillaume B, Schuitemaker Hanneke
Abstract excerpt
Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential...
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