Article
Neutralization and infectivity characteristics of envelope glycoproteins from human immunodeficiency virus type 1 infected donors whose sera exhibit broadly cross-reactive neutralizing activity.
Virology - 30 Mar 2006
Cham Fatim, Zhang Peng Fei, Heyndrickx Leo, Bouma Peter, Zhong Ping, Katinger Herman, Robinson James, van der Groen Guido, Quinnan Gerald V
Abstract excerpt
In this study, we tested the hypothesis that donors with broadly cross-reactive HIV-1 neutralizing (BCN) sera are infected with viruses encoding envelope glycoproteins (Envs) with unusual immunogenic properties. Cloned env genes were from samples of donors previously identified as having BCN antibodies (BCN donors) and from other donors not known to have such antibodies (non-BCN donors). Neutralization properties...
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