Article
Genetic polymorphisms in androgen receptor-binding sites predict survival in prostate cancer patients receiving androgen-deprivation therapy.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2012
Huang C-N, Huang S-P, Pao J-B, Chang T-Y, Lan Y-H, Lu T-L, Lee H-Z, Juang S-H, Wu P-P, Pu Y-S, Hsieh C-J, Bao B-Y
Abstract excerpt
BACKGROUND: Activated androgen receptor binds to androgen-responsive elements (AREs) in genome to regulate target gene transcription and, consequently, mediates physiological or tumorigenic processes of the prostate. Our aim was to determine whether genetic variants in AREs are associated with clinical outcomes after androgen-deprivation therapy (ADT) in prostate cancer patients. PATIENTS AND METHODS: We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.