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Article

Molecular markers in sex hormone pathway genes associated with the efficacy of androgen-deprivation therapy for prostate cancer.

PloS one - 1 Jan 2013

Yu Chia-Cheng, Huang Shu-Pin, Lee Yung-Chin, Huang Chao-Yuan, Liu Chia-Chu, Hour Tzyh-Chyuan, Huang Chun-Nung, You Bang-Jau, Chang Ta-Yuan, Huang Chun-Hsiung, Bao Bo-Ying

Abstract excerpt

Although most advanced prostate cancer patients respond to androgen-deprivation therapy (ADT), the efficacy is widely variable. We investigated whether the host genetic variations in sex hormone pathway genes are associated with the efficacy of ADT. A cohort of 645 patients with advanced prostate cancer treated with ADT was genotyped for 18 polymorphisms across 12 key genes involved in androgen and estrogen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23359804
DOI: 10.1371/journal.pone.0054627
PMCID: PMC3554749

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