Article
Polymorphisms inside microRNAs and microRNA target sites predict clinical outcomes in prostate cancer patients receiving androgen-deprivation therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2011
Bao Bo-Ying, Pao Jiunn-Bey, Huang Chun-Nung, Pu Yeong-Shiau, Chang Ta-Yuan, Lan Yu-Hsuan, Lu Te-Ling, Lee Hong-Zin, Juang Shin-Hun, Chen Lu-Min, Hsieh Chi-Jeng, Huang Shu-Pin
Abstract excerpt
PURPOSE: Recent evidence indicates that small noncoding RNA molecules, known as microRNAs (miRNAs), are involved in cancer initiation and progression. We hypothesized that genetic variations in miRNAs and miRNA target sites could be associated with the efficacy of androgen-deprivation therapy (ADT) in men with prostate cancer. EXPERIMENTAL DESIGN: We systematically evaluated 61 common single nucleotide...
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