Article
Isoform-selective deficit of glycine receptors in the mouse mutant spastic.
Neuron - 1 Feb 1992
Becker C M, Schmieden V, Tarroni P, Strasser U, Betz H
Abstract excerpt
The mutant mouse spastic (spa) develops a characteristic motor disorder about 2 weeks after birth, with symptoms resembling sublethal poisoning by the glycinergic antagonist strychnine. Correspondingly, adult homozygotic mutants (spa/spa) exhibit a severe reduction of inhibitory glycine receptors in spinal cord and brain. Here we show that the spastic mutation selectively interferes with the postnatal...
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