Article
Isoform-selective deficit of glycine receptors in the mouse mutant spastic.
Neuron - 1 Feb 1992
Becker C M, Schmieden V, Tarroni P, Strasser U, Betz H
Abstract excerpt
The mutant mouse spastic (spa) develops a characteristic motor disorder about 2 weeks after birth, with symptoms resembling sublethal poisoning by the glycinergic antagonist strychnine. Correspondingly, adult homozygotic mutants (spa/spa) exhibit a severe reduction of inhibitory glycine receptors in spinal cord and brain. Here we show that the spastic mutation selectively interferes with the postnatal...
Topics
- Age Factors
- Animals
- Blotting, Northern
- Blotting, Western
- Female
- Gene Expression
- Homozygote
- Isomerism
- Mice
- Mice, Mutant Strains
- Muscle Spasticity
- Mutation