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Article

Low level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic mice.

The EMBO journal - 15 Mar 1996

Hartenstein B, Schenkel J, Kuhse J, Besenbeck B, Kling C, Becker C M, Betz H, Weiher H

Abstract excerpt

Mutations in inhibitory glycine receptor (GlyR) subunit genes are associated with neuromotor diseases in man and mouse. To use the potential of the mouse mutants as animal models of human disease, we altered GlyR levels in mutant mice and studied their phenotype. A transgene coding for the beta subunit of the rat GlyR was introduced into the genetic background of the spa mutation, which is characterized by low...

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PMID: 8635460
PMCID: PMC450030

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