Article
Low level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic mice.
The EMBO journal - 15 Mar 1996
Hartenstein B, Schenkel J, Kuhse J, Besenbeck B, Kling C, Becker C M, Betz H, Weiher H
Abstract excerpt
Mutations in inhibitory glycine receptor (GlyR) subunit genes are associated with neuromotor diseases in man and mouse. To use the potential of the mouse mutants as animal models of human disease, we altered GlyR levels in mutant mice and studied their phenotype. A transgene coding for the beta s...
Topics
- Animals
- Base Sequence
- Brain
- Brain Chemistry
- Disease Models, Animal
- Glycine Agents
- In Situ Hybridization
- Membranes
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Neuromuscular Diseases
- Pedigree
- Phenotype
- RNA, Messenger
- Receptors, Glycine
- Spinal Cord
- Strychnine