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Helicobacter <i>pylori</i> induces promoter hypermethylation and downregulates gene expression of IRX1 transcription factor on human gastric mucosa

7 Jun 2011

Abstract excerpt

BACKGROUND AND AIM: Gene silence of IRX1 tumor suppressor by promoter CpG methylation combined with loss of heterozygosity (LOH) has been identified in human gastric cancer. This study investigated the association between methylation of IRX1 and Helicobacter pylori infection in gastric mucosa tissues and cell line. METHODS: IRX1 methylation was studied by methylation specific polymerase chain reaction (MSP) and...

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PMID: 21649733
DOI: 10.1111/j.1440-1746.2011.06808.x

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