Article
Helicobacter pylori infection associated DNA methylation in primary gastric cancer significantly correlates with specific molecular and clinicopathological features.
Molecular carcinogenesis - 1 Feb 2024
Tahara Sayumi, Tahara Tomomitsu, Yamazaki Jumpei, Shijimaya Takuya, Horiguchi Noriyuki, Funasaka Kohei, Fukui Toshiro, Nakagawa Yoshihito, Shibata Tomoyuki, Naganuma Makoto, Tsukamoto Tetsuya, Ohmiya Naoki
Abstract excerpt
Helicobacter pylori induces DNA methylation in gastric mucosa, which links to gastric cancer (GC) risk. In contrast, CpG island methylator phenotype (CIMP) is defined as high levels of cancer-specific methylation and provides distinct molecular and clinicopathological features of GC. The association between those two types of methylation in GC remains unclear. We examined DNA methylation of well-validated H....
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