Genetics of mouse hepatitis virus transcription: identification of cistrons which may function in positive and negative strand RNA synthesis.

doi:10.1016/0042-6822(90)90529-z

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Article

Genetics of mouse hepatitis virus transcription: identification of cistrons which may function in positive and negative strand RNA synthesis.

Virology - 1 Aug 1990

Schaad M C, Stohlman S A, Egbert J, Lum K, Fu K, Wei T, Baric R S

Abstract excerpt

A panel of 26 temperature-sensitive mutants of MHV-A59 were selected by mutagenesis with either 5-fluorouracil or 5-azacytidine. Complementation analysis revealed the presence of one RNA+ and five RNA- complementation groups. None of the RNA- complementation groups transcribed detectable levels o...

Topics

Animals
Cell Line
Genes, Viral
Genetic Complementation Test
Kinetics
L Cells
Mice
Murine hepatitis virus
Mutation
Phenotype
RNA, Viral
Temperature
Transcription, Genetic
Viral Structural Proteins

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